known-motif-enrichment
This skill should be used when users need to perform known motif enrichment analysis on ChIP-seq, ATAC-seq, or other genomic peak files using HOMER (Hypergeometric Optimization of Motif EnRichment). I…
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This skill should be used when users need to perform known motif enrichment analysis on ChIP-seq, ATAC-seq, or other genomic peak files using HOMER (Hypergeometric Optimization of Motif EnRichment). I…
This skill performs differential topologically associating domain (TAD) analysis using HiCExplorer's hicDifferentialTAD tool. It compares Hi-C contact matrices between two conditions based on existing…
Extracts and analyzes competitors' ads from ad libraries (Facebook, LinkedIn, etc.) to understand what messaging, problems, and creative approaches are working. Helps inspire and improve your own ad c…
Execute tasks with velocity and quality. Use when ready to implement after clarity and prioritization are complete. This is the fourth system in the 5-system framework.
This skill generates normalized BigWig (.bw) tracks (and/or fold-change tracks) from BAM files for ATAC-seq and ChIP-seq visualization. It handles normalization (RPM or fold-change) and Tn5 offset cor…
Ethical people-finding. USE WHEN find person, locate, reconnect, people search, skip trace. SkillSearch('privateinvestigator') for docs.
Web accessibility specialist for WCAG compliance, ARIA implementation, and inclusive design. Use when auditing websites for accessibility issues, implementing WCAG 2.1 AA/AAA standards, testing with s…
This skill should be used when the user asks to "attack Active Directory", "exploit AD", "Kerberoasting", "DCSync", "pass-the-hash", "BloodHound enumeration", "Golden Ticket", "Silver Ticket", "AS-REP…
This skill is used to perform genomic feature annotation and visualization for any file containing genomic region information using Homer (Hypergeometric Optimization of Motif EnRichment). It annotate…
This skill performs differential DNA methylation analysis (DMRs and DMCs) between experimental conditions using WGBS methylation tracks (BED/BedGraph). It standardizes input files into per-sample four…
Creates high-quality content (blog posts, tweets, newsletters, documentation) that matches the user's writing style and voice. Performs web research to find citations and supporting evidence. Use when…
Performs ChIP-specific biological validation. It calculates metrics unique to protein-binding assays, such as Cross-correlation (NSC/RSC) and FRiP. Use this when you have filtered the BAM file and cal…
The differential-region-analysis pipeline identifies genomic regions exhibiting significant differences in signal intensity between experimental conditions using a count-based framework and DESeq2. It…
Use when reviewing UI diffs, accessibility audits, or flaky UI tests to catch a11y regressions, semantic issues, keyboard/focus problems, and to recommend minimal fixes plus role-based test selectors.
Implement WCAG 2.1 AA accessibility compliance with ARIA labels, keyboard navigation, screen reader support, and color contrast. Use when ensuring accessibility or fixing a11y issues.
Create React dialog components with forms for the dealflow-network project using Radix UI, tRPC mutations, and proper state management. Use when adding create/edit dialogs, modals, or form-based UI co…
Automatically detect and normalize Hi-C data. Only .cool or .mcool file is supported. All .mcool files are then checked for existing normalization (supports bins/weight only) and balanced if none of t…
This skill provides a complete and streamlined workflow for performing methylation variability and epigenetic heterogeneity analysis from whole-genome bisulfite sequencing (WGBS) data. It is designed …
Prioritize tasks and issues to determine what to work on and in what order. Use after identification, when planning work, or when unsure what to do next. This is the third system in the 5-system frame…
Create and edit Obsidian Bases (.base files) with views, filters, formulas, and summaries. Use when working with .base files, creating database-like views of notes, or when the user mentions Bases, ta…
Create irresistible offers and pitches using Alex Hormozi's methodology from $100M Offers. Guides through value equation, guarantee frameworks, pricing psychology, and creating offers "too good not to…
Use when executing implementation plans with independent tasks in the current session
Plan accessibility compliance - WCAG 2.2, Section 508, EN 301 549, inclusive design principles, audit planning, and remediation strategies.
Create domain layer components: models, repository interfaces, marshallers, and implementations. Use when: (1) adding domain model in internal/domain/model/, (2) creating repository interface in inter…