Fusion Gene Detector Skill

Purpose

Enable gene fusion detection for oncology applications with multiple caller integration.

Capabilities

• RNA-based fusion calling
• DNA-based fusion detection
• Multi-caller consensus
• Visualization of fusion events
• Known fusion annotation
• Clinical actionability assessment

Usage Guidelines

• Use multiple callers for sensitivity
• Build consensus from different algorithms
• Annotate with known fusion databases
• Visualize fusion breakpoints
• Assess clinical actionability
• Document caller combinations

Dependencies

• STAR-Fusion
• Arriba
• FusionCatcher

Process Integration

• Tumor Molecular Profiling (tumor-molecular-profiling)
• RNA-seq Differential Expression Analysis (rnaseq-differential-expression)