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download-sra
Download raw sequencing data from NCBI SRA as FASTQ files using prefetch and fasterq-dump, with support for single accessions, batch lists, and BioProject expansion.
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Skill 资源库
AI Skill 资源库
把 Skill 的源码、资源快照、README、包体和安装信号放进一个可搜索、可筛选的公开目录。
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estimate-immune-score-analysis
Use this skill to compute ESTIMATE immune-related microenvironment scores from a bulk expression matrix, generate an ESTIMATE score heatmap, and optionally generate group-wise ESTIMATE score boxplots …
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fair-esm2
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genome-read-alignment
Align short reads to a reference genome with BWA-MEM2, sort and index with samtools, and mark duplicates with picard.
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genome-variant-filtering
Filter raw variant calls using GATK VQSR, GATK hard filters, or bcftools expression-based filtering.
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grant-writing-eu
Drafting and reviewing European fellowship and grant applications (Marie Skłodowska-Curie Actions, Horizon Europe, ERC, EIC). Covers the Excellence/Impact/Implementation triad, gender dimension and se…
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pediatric-growth-charts
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pi-deep-research
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elastic-net-feature-selection
Use when selecting predictive genes or other molecular features from bulk expression matrices for binary case-vs-control classification with elastic net logistic regression, including coefficient path…
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evo2
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fair-simulation-packager
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genome-variant-annotation
Annotate variants with functional effects using SnpEff or Ensembl VEP, adding gene impact, population frequencies, and clinical significance.
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geomaster
Comprehensive geospatial science skill covering remote sensing, GIS, spatial analysis, machine learning for earth observation, and 30+ scientific domains. Supports satellite imagery processing (Sentin…
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graphical-abstract-generator
Converts a biomedical study storyline into a graphical abstract and, when direct image capability is available, generates the graphical abstract directly; otherwise it falls back to prompts, Mermaid f…
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peft-fine-tuning
Parameter-efficient fine-tuning for LLMs using LoRA, QLoRA, and 25+ methods. Use when fine-tuning large models (7B-70B) with limited GPU memory, when you need to train <1% of parameters with minimal a…
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pipeline-manifest
Build a traceability manifest linking analysis scripts to inputs, outputs, and manuscript figures or tables. Use when documenting a computational pipeline or locating the source of a reported artefact…
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esmfold2
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external-model-validation
Use when validating an existing prognostic risk signature on an external bulk expression cohort with survival outcomes, producing risk scores, Kaplan-Meier curves, risk distribution plots, heatmap, an…
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genome-alignment-qc
Assess alignment quality with coverage depth, mapping rates, insert size, and on-target metrics using samtools, mosdepth, and picard.
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genome-variant-calling
Call SNVs and indels from aligned BAMs using GATK HaplotypeCaller or DeepVariant with optional GVCF output for joint genotyping.
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grant-specific-aims-writer
Writes Specific Aims pages for grant applications. Use when drafting or revising the Specific Aims page (NIH R01/R21/R03), NSF Project Summary, or equivalent for any major funding agency. Also trigger…
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grpo-rl-training
Expert guidance for GRPO/RL fine-tuning with TRL for reasoning and task-specific model training
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phylogenetics
Build and analyze phylogenetic trees using MAFFT (multiple alignment), IQ-TREE 2 (maximum likelihood), and FastTree (fast NJ/ML). Visualize with ETE3 or FigTree. For evolutionary analysis, microbial g…
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pm-advanced-search
Perform advanced PubMed search with field qualifiers - author, title, journal, MeSH, date range, article type. Constructs proper PubMed query syntax from natural language. Use for precise filtered sea…
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